AMP-activated protein kinase (AMPK) senses cellular energy. AMPK activation regulates metabolism in skeletal muscle, the liver, heart, pancreas, and adipose tissue. Obesity-related fuel metabolism deficits cause type 2 diabetes. In type 2 diabetes, insulin resistance is most evident in skeletal muscle, where glucose and fatty acids are consumed. So, activating AMPK is therapeutic for type 2 diabetes.
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